專家簡介:鍾志宏


鍾志宏博士具備生命科學背景與分子生物實驗室訓練,專長於結合臨床問題與基礎研究科學研究的轉譯醫學研究。

研究領域:

臨床頭頸癌癌症轉移分子生物研究


學歷:

國立陽明交通大學中研院國際研究生分子醫學博士學位學程博士

國立陽明大學生化暨分子生物研究所碩士


經歷:

國立陽明大學臨床醫學研究所博士後


專長:

  • 分子生物技術與腫瘤小鼠模型(PDX, Immune cell profiling)
  • 轉錄體定序數據分析 (Single cell RNAseq)
  • 空間轉錄體RNA分析 (10x VISIUM)
  • 高通量螢光臨床檢體表現分析 (Vectra Polariss)

研究成果:

  1. Chih-Hung Chung, Chun-Yu Lin, Chih-Yu Chen, Chun-Wei Hsueh, Pen-Yuan Chu, Shyh-Kuan Tai and Muh-Hwa Yang Ferroptosis signature shapes the immune profiles to enhance the response to immune checkpoint inhibitors in head and neck cancer Advanced Science (2023) doi:10.1002/advs.202204514
  2. Da-Liang Ou, Chia-Wei Chen, Chia-Lang Hs, Chih-Hung Chung, Zi-Rui Feng, Bin-Shyun Lee, Ann-Lii Cheng, Muh-Hwa Yang,Chiun Hsu Regorafenib enhances antitumor immunity via inhibition of p38 kinase/Creb1/Klf4 axis in tumor-associated macrophages J Immunother Cancer (2021) DOI: 10.1136/jitc-2020-001657
  3. Lin SC, Chung CH, Chung CH, Kuo MH, Hsieh CH, Chiu YF, Shieh YS, Chou YT, Wu CW OCT4B mediates hypoxia-induced cancer dissemination. Oncogene. (2019) doi: 10.1038/s41388-018-0487-6Y-T Chou, C-H Hsieh, S-H
  4. Lin SC, Chou YT, Jiang SS, Chang JL, Chung CH, Kao YR, Chang IS, Wu CW (2016) Epigenetic Switch between SOX2 and SOX9 Regulates Cancer Cell Plasticity. Cancer Res. (1 Dec 2016) doi: 10.1158/0008-5472
  5. Chiou, C-F Hsu, Y-R Kao, C-C Lee, C-H Chung, Y-H Wang, H-S Hsu, S-T Pang, Y-S Shieh and C-W Wu. (2012) CITED2 functions as a molecular switch of cytokine-induced proliferation and quiescence. Cell Death & Differentiation , (2012) | doi:10.1038/cdd.2012.91

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