專家簡介: 劉孜孜

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劉孜孜博士在定序技術有超過十年的經驗，參與過人類基因體計劃及多項大型基因體定序計劃，熟悉傳統定序到次世代定序技術操作及各種技巧，也是國內多項次世代定序技術的引進者，在基因體中心服務期間，成功引進多種定序應用，例如表觀基因體定序、降解體定序等技術，是國內定序技術首屈一指的專家。

研究領域：

Genomic, Sequencing, Genotyping

學歷：
理學博士     1997        陽明大學 生物化學研究所


經歷：
副研究員        2015.2-迄今   陽明大學 榮陽基因體研究中心
助理研究員    2002.2-2015.1       陽明大學 榮陽基因體中心
博士後研究    1997.8-2002.1       陽明大學 遺傳學研究所


專長：

生化遺傳學, 醫學遺傳學, 基因體定序


研究成果：

  1. Lin MW, Lee DD, Liu TT, Lin YF, Chen SY, Huang CC, Weng HY, Liu YF, Tanaka A, Arita K, Lai-Cheong J, Palisson F, Chang YT, Wong CK, Matsuura I, McGrath JA, Tsai SF. Novel IL31RA gene mutation and ancestral OSMR mutant allele in familial primary cutaneous amyloidosis. Eur J Hum Genet. 2010;18:26-32.
  2. Cheng KH, Liu MY, Kao CH, Chen YJ, Hsiao KJ, Liu TT, Lin HY, Huang CH, Chiang CC, Ho HJ, Lin SP, Lee NC, Hwu WL, Lin JL, Hung PY, Niu DM. Newborn Screening for Methylmalonic Aciduria by Tandem Mass Spectrometry: 7 Years’ Experience From Two Centers in Taiwan. J Chin Med Assoc 2010;73:314–318.
  3. Niu DM, Chien YH, Chiang CC, Ho HC, Hwu WL, Kao SM, Chiang SH, Kao CH, Liu TT, Chiang H, Hsiao KJ. Nationwide survey of extended newborn screening by tandem mass spectrometry in Taiwan. J Inherit Metab Dis 2010;33(Suppl 2):S295-305
  4. Liu MY, Yang YL, Chang YC, Chiang SH, Lin SP, Han LS, Qi Y, Hsiao KJ, Liu TT. Mutation spectrum of MMACHC in Chinese patients with combined methylmalonic aciduria and homocystinuria. J Hum Genet 2010;55:621-626
  5. Lin HC, Yang YY, Tsai TH, Huang CM, Huang YT, Lee FY, Liu TT, Lee SD. The relationship between endotoxemia and hepatic endocannabinoids in cirrhotic rats with portal hypertension. J Hepatol. 2011;54:1145-53
  6. Tsai YC, Chiao CH, Chang YF, Chen DT, Liu TT, Hua K, Chang CH, Hsu MT. Common Altered Epigenomic Domains in Cancer Cells: Characterization and Subtle Variation. Cancers. 2011;3:1996-2013
  7. Huang SW, Lin YY, You EM, Liu TT, Shu HY, Wu KM, Tsai SF, Lo CF, Kou GH, Ma GC, Chen M, Wu D, Aoki T, Hirono I, Yu HT. Fosmid library end sequencing reveals a rarely known genome structure of marine shrimp Penaeus monodon. BMC Genomics. 2011;12:242
  8. Liao WC, Ng WV, Lin IH, Syu WJ, Liu TT, Chang T4-like Genome Organization of the Escherichia coli O157:H7 Lytic Phage AR1. J Virol. 2011; 85:6567-78.
  9. Lin IH, Liu TT, Teng YT, Wu HL, Liu YM, Wu KM, Chang CH, Hsu MT. Sequencing and Comparative Genome Analysis of Two Pathogenic Streptococcus gallolyticus Subspecies: Genome Plasticity, Adaptation and Virulence. PLoS ONE 2011;6: e20519. doi:10.1371
  10. Shu HW, Liu TT, Chang HY, Liu YM, Wu KM, Shu HY, Tsai SF, Hsiao KJ, Hu WS, Ng WV. Genome sequence of the repetitive sequence rich Mycoplasma fermentans strain M64. J Bacteriol. 2011;193:4302-3
  11. Chang JT, Chen YY, Liu TT, Liu MY, Chiu PC. Combined methylmalonic aciduria and homocystinuria cblC type of a Taiwanese infant with c.609G>A and C.567dupT mutations in the MMACHC gene. Pediatr Neonatol. 2011; 52:223-6.
  12. Liu MY, Liu TT, Yang YL, Chang YC, Fan YL, Lee SF, Teng YT, Chiang SH, Niu DM, Lin SJ, Chao MC, Lin SP, Han LS, Qi Y, Hsiao KJ. Mutation profile of the MUT gene in Chinese methylmalonic aciduria patients. JIMD Reports, 2012; 6:55-64. DOI: 10.1007/8904_2011_117. Epub 2012 Jan 31.
  13. Chiu YH , Chang YC, Chang YH, Niu DM , Yang YL, Ye J, Jiang JH, Okano Y, Lee DH, Pangkanon S, Kuptanon C, Hock NL, Chiong MA, Cavan BV, Hsiao KJ, Liu TT. Mutation spectrum of and founder effects affecting the PTS gene in East Asian population. J Hum Genet. 2012;57:145-52
  14. Shu HW, Liu TT, Chan HI, Liu YM, Wu KM, Shu HY, Tsai SF, Hsiao KJ, Hu WS, Ng WV. Complexity of the Mycoplasma fermentans M64 Genome and Metabolic Essentiality and Diversity among Mycoplasmas. PLoS One. 2012;7:e32940.
  15. Lin GH, Chen HP, Huang JH, Liu TT, Lin TK, Wang SJ, Tseng CH, Shu HY. Identification and characterization of an indigo-producing oxygenase involved in indole 3-acetic acid utilization by Acinetobacter baumannii. Antonie Van Leeuwenhoek. 2012;101:881-90.
  16. Lee YC, Durr A, Majczenko K, Huang YH, Liu YC, Lien CC, Tsai PC, Ichikawa Y, Goto J, Monin ML, Li JZ, Chung MY, Mundwiller E, Shakkottai V, Liu TT, Tesson C, Lu YC, Brice A, Tsuji S, Burmeister M, Stevanin G, Soong BW. Mutations in KCND3 cause spinocerebellar ataxia type 22. Annals of Neurology, 2012; 72:859-69.
  17. Soong BW, Huang YH, Tsai PC, Huang CC, Pan HC, Lu YC, Chien HJ, Liu TT, Chang MH, Lin KP, Tu PH, Kao LS, Lee YC. Exome Sequencing Identifies GNB4 Mutations as a Cause of Dominant Intermediate Charcot-Marie-Tooth Disease. Am J Hum Genet. 2013; 92:422-30.
  18. Ko MSA, Tu HP, Liu TT, Chang JG, Yuo CY, Chiang SL, Chang SJ, Liu YF, Min-Jen Ko A, Lee CH, Lee CP, Chang CM, Tsai SF, Ko YC. ALPK1 genetic regulation and risk in relation to gout. Int J Epidemiol. 2013; 42:466-474.
  19. Huang YH, Wu HY, Wu KM, Liu TT, Liou RF, Tsai SF, Shiao MS, Ho LT, Tzean SS, Yang UC. Generation and Analysis of the Expressed Sequence Tags from the Mycelium of Ganoderma lucidum. PLoS ONE 2013; 8(5): e61127. doi:10.1371/journal.pone.0061127
  20. Chiu YH, Liu YN, Liao WL, Chang YC, Lin SP, Hsu CC, Chiu PC, Niu DM, Wang CH, Ke YY, Chien YH, Hsiao KJ, Liu TT. Two Frequent Mutations Associated with the Classic Form of Propionic Acidemia in Taiwan. Biochem Genet. 2014; 52:415-29. DOI: 10.1007/s10528-014-9657-6
  21. Tsai PC, Huang YH, Guo YC, Wu HT, Lin KP, Tsai YS, Liao YC, Liu YT, Liu TT, Kao LS, Yet SF, Fann MJ, Soong BW, Lee YC. A novel TFG mutation causes Charcot-Marie-Tooth disease type 2 and impairs TFG function. 2014;83(10):903-12. doi: 10.1212/WNL.0000000000000758. Epub 2014 Aug 6.
  22. Lin IH, Chen DT, Chang YF, Lee YL, Su CH, Cheng C, Tsai YC, Ng SC, Chen HT, Lee MC, Chen HW, Suen SH, Chen YC, Liu TT, Chang CH, Hsu MT. Hierarchical clustering of breast cancer methylomes revealed differentially methylated and expressed breast cancer genes. PLoS One. 2015;10(2):e0118453. doi: 10.1371/journal.pone.0118453.
  23. Baldrich P, Campo S, Wu MT, Liu TT, Hsing YI, Segundo BS. MicroRNA-mediated regulation of gene expression in the response of rice plants to fungal elicitors. RNA Biol. 2015;12(8):847-863. doi: 10.1080/15476286.2015.1050577.

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